Human Cytomegalovirus-Induced Chromosomal Damage: Potential Role in Sensorineural Manifestations of the Congenitally Infected Infant
HCMV is the leading viral cause of birth defects. The primary outcomes of infection are deafness and blindness. We have found that infection of cells in tissue culture leads to specific chromosomal damage. We will investigate the damage induction process and its propagation in cell types infected in utero. We hope to further understand the mechanism behind HCMV-induced central nervous system damage in the infected infant.