The Evolution of Protein Flexibility Grant uri icon



  • There is a lack of information characterizing the partially collapsed flexible structures of proteins, which inhibits our ability to predict their existence based on sequence data. It also limits our understanding of how the sequences of such regions specify function, the presence of residual structure, and the degree of flexibility. While the presence and importance of the partially collapsed, flexible structures of proteins in nature is well established, this proposal marks the first systematic empirical investigation into their evolutionary constraints and patterns.

date/time interval

  • September 1, 2001 - June 30, 2007

sponsor award ID

  • IDA01229