The Transcriptome and Transcriptional Regulatory Network of the Aspergillus Nidulans Sexual Cycle
An understanding of the sexual reproductive transcriptome and its regulation in A. nidulans should provide important insights into the reproductive biology of filamentous fungi and ultimately, the regulatory relationship between homothallic (self fertile) and heterothallic (self sterile, cross fertile) fungal species. Of interest is the possibility of identifying ways to manipulate the potential cryptic sexual cycle of the asexual human pathogen A. fumigatus. This could provide provide valuable genetic tools that can be used to identify and manipulate genes encoding A.fumigatus virulence factors. The purpose of this project is to generate a detailed, genome wide picture of gene expression controlling sexual reproduction in fungi.