selected publications
-
academic article
- Structure of Hsp90-p23-GR reveals the Hsp90 client-remodelling mechanism. Nature. 601:465-+. 2022
- Structure of Hsp90-Hsp70-Hop-GR reveals the Hsp90 client-loading mechanism. Nature. 601:460-+. 2022
- EfgA is a Conserved Formaldehyde Sensor That Leads to Bacterial Growth Arrest in Response to Elevated Formaldehyde. PLOS Biology. 19:e3001208. 2021
- Disrupting progression of the yeast Hsp90 folding pathway at different transition points results in client-specific maturation defects. Genetics. 217. 2021
- First Virtual International Congress on Cellular and Organismal Stress Responses, November 5-6, 2020. Cell Stress and Chaperones. 26:289-295. 2021
- Human Hsp90 Cochaperones: Perspectives on Tissue-specific Expression and Identification of Cochaperones with Similar in Vivo Functions. Cell Stress and Chaperones. 2020
- The conserved NxNNWHW motif in Aha-type co-chaperones modulates the kinetics of Hsp90 ATPase stimulation. Nature Communications. 10:1273. 2019
- Functional and physical interaction between yeast Hsp90 and Hsp70. Proceedings of the National Academy of Sciences of the United States of America. 115:E2210-E2219. 2018
- An Hsp90 co-chaperone protein in yeast is functionally replaced by site-specific posttranslational modification in humans. Nature Communications. 8.0. 2017
- Rad25 Protein Is Targeted for Degradation by the Ubc4-Ufd4 Pathway. Journal of Biological Chemistry. 290:8606-8612. 2015
- The Hsp90 Cochaperones Cpr6, Cpr7, and Cns1 Interact with the Intact Ribosome. Eukaryotic Cell. 14:55-63. 2015
- Mutation of essential Hsp90 co-chaperones SGT1 or CNS1 renders yeast hypersensitive to overexpression of other co-chaperones. Current Genetics. 60:265-276. 2014
- Chaperoning the chaperone: a role for the co-chaperone Cpr7 in modulating Hsp90 function in Saccharomyces cerevisiae.. Genetics. 191:805-U234. 2013
- Evolution and function of diverse Hsp90 homologs and cochaperone proteins.. Biochimica et Biophysica Acta. 1823. 2013
- Identification of an Hsp90 mutation that selectively disrupts cAMP/PKA signaling in Saccharomyces cerevisiae.. Current Genetics. 58. 2013
- A global view of Hsp90 functions. Nature. Structural and Molecular Biology. 20:1-4. 2013
- Hsp90 and co-chaperones twist the functions of diverse client proteins. Biopolymers. 93:211-217. 2010
- Ubr1 and Ubr2 Function in a Quality Control Pathway for Degradation of Unfolded Cytosolic Proteins. Molecular Biology of the Cell. 21:2102-2116. 2010
- Glaucoma-associated {WDR36} variants encode functional defects in a yeast model system. Human Molecular Genetics. 18:1276-1287. 2009
- Plasticity of the Hsp90 chaperone machine in divergent eukaryotic organisms. Cell Stress and Chaperones. 14:83-94. 2009
- Farnesylation of Ydj1 is required for in vivo interaction with Hsp90 client proteins.. Molecular Biology of the Cell. 19. 2008
- Definition of the minimal fragments of Sti1 required for dimerization, interaction with Hsp70 and Hsp90 and in vivo functions.. The Biochemical Journal. 404. 2007
- Nucleotide-dependent interaction of Saccharomyces cerevisiae Hsp90 with the cochaperone proteins Sti1, Cpr6, and Sba1.. Molecular and Cellular Biology. 27. 2007
- Effect of mutation of the tetratricopeptide repeat and asparatate-proline 2 domains of Sti1 on Hsp90 signaling and interaction in Saccharomyces cerevisiae.. Genetics. 172. 2006
- Novel interaction of the Hsp90 chaperone machine with Ssl2, an essential DNA helicase in Saccharomyces cerevisiae.. Current Genetics. 47. 2005
-
chapter
- The role of p23, Hop, immunophilins, and other co-chaperones in regulating Hsp90 function. Molecular Chaperones: Methods and Protocols. 45-66. 2011