Publications in VIVO

Co-author Network

Diana M Mitchell Assistant Professor

Positions

Participating Faculty, Institute for Modeling Collaboration and Innovation (IMCI)
Affiliate Faculty, Neuroscience , College of Graduate Studies
Assistant Professor, Biological Sciences , College of Science
Member, Institute for Bioinformatics and Evolutionary Studies (IBEST) , Institute for Interdisciplinary Data Sciences (IIDS)

My current research interests involve immune cell function in the central nervous system, specifically the retina. I am particularly interested in microglia, which are resident innate immune cells of the central nervous system. Current efforts employ the zebrafish model system and seek to understand the role of microglia in the development of the retina, how microglia respond to neuronal cell death, and how they may support or be detrimental to neuronal regeneration.

I also contribute to research efforts in Dr. Deborah Stenkamp’s lab, where we are investigating mechanisms of photoreceptor fate decisions in the developing retina.

Publications

selected publications

academic article
- Compensatory engulfment and Muller glia reactivity in the absence of microglia. Glia. 70:1402-1425. 2022
- Modulation of retinoid-X-receptors differentially regulates expression of apolipoprotein genes apoc1 and apoeb by zebrafish microglia. Biology Open. 11. 2022
- Evidence of regional specializations in regenerated zebrafish retina. Experimental Eye Research. 212. 2021
- Bioinformatic Analysis and Functional Predictions of Selected Regeneration-Associated Transcripts Expressed by Zebrafish Microglia. BMC Genomics. 21:870. 2020
- Microglia in the Developing Retina Couple Phagocytosis with the Progression of Apoptosis via P2RY12 Signaling. Developmental Dynamics. 249:723-740. 2020
- Endocrine regulation of multichromatic color vision. Proceedings of the National Academy of Sciences of the United States of America. 116:16882-16891. 2019
- Rapid macrophage-mediated clearance of apoptosis-fated cells during zebrafish retinal development. Investigative Ophthalmology and Visual Science. 60. 2019
- Regeneration associated transcriptional signature of retinal microglia and macrophages. Scientific Reports. 9:4768. 2019
- Topographic Patterns of Regenerated Retinal Neurons in Zebrafish. Investigative Ophthalmology and Visual Science. 60. 2019
- Dynamic changes in microglial and macrophage characteristics during degeneration and regeneration of the zebrafish retina. Journal of Neuroinflammation. 15:163. 2018
- Isolation of photoreceptors from mature, developing, and regenerated zebrafish retinas, and of microglia/macrophages from regenerating zebrafish retinas.. Experimental Eye Research. 177:130-144. 2018
- Transcriptome Analysis of Zebrafish Microglia During Retinal Regeneration. Investigative Ophthalmology and Visual Science. 59. 2018
- Retinoic Acid Signaling Regulates Differential Expression of the Tandemly-Duplicated Long Wavelength-Sensitive Cone Opsin Genes in Zebrafish. PLOS Genetics. 11. 2015
- Protease-Dead Separase is Dominant Negative in the C. elegans Embryo. PLOS One. 9. 2014
- Bim mediates the elimination of functionality unfit Th1 responders from the memory pool. PLOS One. 8:e67363. 2013
- Disparate roles for STAT5 in primary and secondary CTL responses. Journal of Immunology. 190:3390-3398. 2013
- Distinct roles for IL-2 and IL-15 in the differentiation and survival of CD8+ Effector and Memory T cells. Journal of Immunology. 184:6719-6730. 2010
- An Activation Marker Finds a Function. Immunity. 32:9-11. 2010

Contact

full name

Diana M Mitchell