Publications in VIVO

Bryn A Martin Director, Assistant Professor

Positions

Participating Faculty, Institute for Modeling Collaboration and Innovation
Director, Neurophysiological Imaging and Modeling Laboratory (NIML) , Biological Engineering
Member, Institute for Bioinformatics and Evolutionary Studies (IBEST) , University of Idaho
Assistant Professor, Biological Engineering , College of Engineering 2015 -

Bryn Martin is an Associate Professor of Biological Engineering at The University of Idaho Department of Biological Engineering. From 2012-15, Dr. Martin served as the 1st Director of the Conquer Chiari Research Center at the University of Akron. He completed his post-doctoral training from 2009-2012 at the Swiss Federal Institute of Technology EPFL Laboratory of Hemodynamics and Cardiovascular Technology. He completed a Ph.D. in mechanical engineering at the University of Illinois at Chicago focused on the biofluid mechanics of syringomyelia and Chiari malformation.

Dr. Martin's research interests include neurohydrodynamics of craniospinal disorders, intrathecal drug delivery, cardiovascular hemodynamics, medical technology and devices and sleep disorders. He is currently a principle investigator and co-investigator for a number of clinical research studies employing MRI, cerebrovascular ultrasound and medical instrumentation. When not in the lab, Dr. Martin's free time is enjoyed writing music and taking walks with his wife and children.

Research Areas

Amyotrophic lateral sclerosis
Arnold-Chiari deformity
Biomechanics
Cerebrospinal fluid--Physiology
Diagnostic imaging
Fracture mechanics
Hydrocephalus
Intracranial hypertension
Magnetic resonance imaging
Molecular biology
Phase contrast magnetic resonance imaging
biological engineering (UMLS)
hemodynamics (UMLS)
intrathecal (UMLS)
medical technology (UMLS)
sleep disorders (UMLS)

Publications

selected publications

academic article
- Intrathecal Catheter Implantation Decreases Cerebrospinal Fluid Dynamics in Cynomolgus Monkeys. Frontiers in Sustainable Food Systems. 15:e0244090. 2020
- Ex-vivo Quantification of Ovine Pia Arachnoid Complex Biomechanical Properties under Uniaxial Tension. Fluids and Barriers of the CNS. 17:68. 2020
- In Vivo Estimation of Optic Nerve Sheath Stiffness Using Noninvasive MRI Measurements and Finite Element Modeling. Journal of the Mechanical Behavior of Biomedical Materials. 110:103924. 2020
- In Vitro and Numerical Simulation of Blood Removal from Cerebrospinal Fluid: Comparison of Lumbar Drain to Neurapheresis Therapy. Fluids and Barriers of the CNS. 17:23. 2020
- Impact of Neurapheresis System on Intrathecal Cerebrospinal Fluid Dynamics: a Computational Fluid Dynamics Study. Journal of Biomechanical Engineering. 142:021006 . 2020
- Non-invasive MRI Quantification of Cerebrospinal Fluid Dynamics in Amyotrophic Lateral Sclerosis Patients. Fluids and Barriers of the CNS. 17. 2020
- Characterization of intrathecal cerebrospinal fluid geometry and dynamics in cynomolgus monkeys (macaca fascicularis) by magnetic resonance imaging. Frontiers in Sustainable Food Systems. 14:e0212239. 2019
- Development of Common Data Elements for Use in Chiari Malformation Type I Clinical Research: An NIH/NINDS Project.. Neurosurgery. 85:854-860. 2019
- Dispersion in porous media in oscillatory flow between flat plates: applications to intrathecal, periarterial and paraarterial solute transport in the central nervous system.. Fluids and Barriers of the CNS. 16:13. 2019
- Cerebellar Tonsil Ectopia Measurement in Type I Chiari Malformation patients show poor inter-operator reliability. Fluids and Barriers of the CNS. 15. 2018
- Cardiac-Related Spinal Cord Tissue Motion at the Foramen Magnum is Increased in Patients with Type I Chiari Malformation and Decreases Postdecompression Surgery. World Neurosurgery. 116:e298-e307. 2018
- A pilot study on the biomechanical assessment of obstructive sleep apnea pre and post bariatric surgery. Respiratory Physiology and Neurobiology. 250:1-6. 2018
- A Retrospective 2D Morphometric Analysis of Adult Female Chiari Type I Patients with Commonly Reported and Related Conditions.. Frontiers in Neuroanatomy. 12:2. 2018
- A morphometric assessment of type I Chiari malformation above the McRae line: A retrospective case-control study in 302 adult female subjects. Journal of Neuroradiology. 45:23-31. 2018
- An Electrophysiological Study of Cognitive and Emotion Processing in Type I Chiari Malformation.. Cerebellum (London, England). 2018
- An MRI-Compatible Hydrodynamic Simulator of Cerebrospinal Fluid Motion in the Cervical Spine. IEEE Transactions on Biomedical Engineering. 65:1516-1523. 2018
- Anthropomorphic Model of Intrathecal Cerebrospinal Fluid Dynamics Within the Spinal Subarachnoid Space: Spinal Cord Nerve Roots Increase Steady-Streaming. Journal of Biomechanical Engineering. 140. 2018
- Machine learning applied to neuroimaging for diagnosis of adult classic Chiari malformation: role of the basion as a key morphometric indicator. Journal of Neurosurgery. 129:779-791. 2018
- Subarachnoid Trabeculae: A Comprehensive Review of Their Embryology, Histology, Morphology, and Surgical Significance. World Neurosurgery. 111:279-290. 2018
- Numerical study of intrathecal drug delivery to a permeable spinal cord: effect of catheter position and angle. Computer Methods in Biomechanics and Biomedical Engineering. 20.0:1599.0-1608.0. 2017
- Quantifying the influence of respiration and cardiac pulsations on cerebrospinal fluid dynamics using real-time phase-contrast MRI. Journal of Magnetic Resonance Imaging. 46.0:431.0-439.0. 2017
- A numerical investigation of intrathecal isobaric drug dispersion within the cervical subarachnoid space.. Frontiers in Sustainable Food Systems. 12. 2017
- Nonuniform Moving Boundary Method for Computational Fluid Dynamics Simulation of Intrathecal Cerebrospinal Flow Distribution in a Cynomolgus Monkey. Journal of Biomechanical Engineering. 139. 2017
- Cerebrospinal fluid velocity amplitudes within the cerebral aqueduct in healthy children and patients with Chiari I malformation. Journal of Magnetic Resonance Imaging. 44:463-470. 2016
- Accuracy of 4D Flow Measurement of Cerebrospinal Fluid Dynamics in the Cervical Spine: An In Vitro Verification Against Numerical Simulation. Annals of Biomedical Engineering. 44:3202-3214. 2016
- Cephalometric oropharynx and oral cavity analysis in Chiari malformation Type I: a retrospective case-control study. Journal of Neurosurgery. 1-8. 2016
- Inter-operator Reliability of Magnetic Resonance Image-Based Computational Fluid Dynamics Prediction of Cerebrospinal Fluid Motion in the Cervical Spine. Annals of Biomedical Engineering. 44:1524-1537. 2016
- Continuous positive airway pressure alters cranial blood flow and cerebrospinal fluid dynamics at the craniovertebral junction. Interdisciplinary Neurosurgery. 2:152-159. 2015
- Cardiac related neural tissue motion impacts cerebrospinal fluid dynamics at the cervical-medullary junction: a patient-specific moving-boundary computational fluid dynamics model of type 1 Chiari malformation. Annals of Biomedical Engineering. 2015
- Characterization of the Discrepancies Between Four-Dimensional Phase-Contrast Magnetic Resonance Imaging and In-Silico Simulations of Cerebrospinal Fluid Dynamics. Journal of Biomechanical Engineering. 137. 2015
- Cerebrospinal Fluid Flow Impedance is Elevated in Type I Chiari Malformation. Journal of Biomechanical Engineering. 136. 2014
- Task-Specific and General Cognitive Effects in Chiari Malformation Type I. Frontiers in Sustainable Food Systems. 9. 2014
- The Impact of Spinal Cord Nerve Roots and Denticulate Ligaments on Cerebrospinal Fluid Dynamics in the Cervical Spine. Frontiers in Sustainable Food Systems. 9. 2014
- The squeeze of Chiari malformation, clinicians and scientists collaborate to understand its cause and effects. Pediatric Neuroscience Pathways. 2014
- Syringomyelia: A review of the biomechanics. Journal of Fluids and Structures. 40:1-24. 2013
- The effect of continuous positive airway pressure on total cerebral blood flow in healthy awake volunteers. Sleep and Breathing. 17:289-296. 2013
- Hydrodynamic and Longitudinal Impedance Analysis of Cerebrospinal Fluid Dynamics at the Craniovertebral Junction in Type I Chiari Malformation. Frontiers in Sustainable Food Systems. 8. 2013
- Method for Dynamic Material Property Characterization of Soft-Tissue-Mimicking Isotropic Viscoelastic Materials Using Fractional Damping Models. Journal of Testing and Evaluation. 41:804-812. 2013
- Where do we stand on the relationship between tau biomarkers and mild cognitive impairment?. Quantitative Imaging in Medicine and Surgery. 3:189-191. 2013
- Ventricle equilibrium position in healthy and normal pressure hydrocephalus brains using an analytical model. Journal of Biomechanical Engineering. 134. 2012
- A coupled hydrodynamic model of the cardiovascular and cerebrospinal fluid system. American Journal of Physiology: Heart and Circulatory Physiology. 302:1492-1509. 2012
- Response to comments regarding Vardoulis O, et al., Impact of Aortic Grafts on Arterial Pressure: A Computational Fluid Dynamics Study. European Journal of Vascular and Endovascular Surgery. 43:238-239. 2012
- Comparison of 4D Phase-Contrast MRI Flow Measurements to Computational Fluid Dynamics Simulations of Cerebrospinal Fluid Motion in the Cervical Spine. Frontiers in Sustainable Food Systems. 7. 2012
- Magnetic resonance 4D flow analysis of cerebrospinal fluid dynamics in Chiari I malformation with and without syringomyelia. European Radiology. 22:1860-1870. 2012
- Impact of Aortic Grafts on Arterial Pressure: A Computational Fluid Dynamics Study. European Journal of Vascular and Endovascular Surgery. 42:704-710. 2011
- Cerebrospinal fluid hydrodynamics in type I Chiari malformation. Neurological Research. 33:247-260. 2011
- Spinal Subarachnoid Space Pressure Measurements in an In Vitro Spinal Stenosis Model: Implications on Syringomyelia Theories. Journal of Biomechanical Engineering. 132. 2010
- MR Measurement of Cerebrospinal Fluid Velocity Wave Speed in the Spinal Canal. IEEE Transactions on Biomedical Engineering. 56:1765-1768. 2009
- The influence of coughing on cerebrospinal fluid pressure in an in vitro syringomyelia model with spinal subarachnoid space stenosis. Cerebrospinal fluid research. 6. 2009
- Transverse vibration of pre-stressed beams: An experimental technique for the determination of dynamic viscoelastic material properties of tissue mimicking materials. Journal of the Acoustical Society of America. 123. 2008
- Acoustic radiation from a fluid-filled, subsurface vascular tube with internal turbulent flow due to a constriction. Journal of the Acoustical Society of America. 118:1193-1209. 2005
- Syringomyelia hydrodynamics: An in vitro study based on in vivo measurements. Journal of Biomechanical Engineering. 127:1110-1120. 2005
chapter
- Anatomy and Physiology of Cerebrospinal Fluid Dynamics. Nervous System Drug Delivery: Principles and Practices. Academic Press. 73-89. 2019
conference paper
- Quantitative comparison of 4D MRI flow measurements to 3D CFD simulation of cerebrospinal fluid movement in the spinal subachnoid space. International Conference on Computational Fluid Dynamics in Medicine and Biology. 2012
conference poster
- 3D printed model of the cervical spine for simulation of cerebrospinal fluid motion: comparison of in vitro computational fluid dynamics simulation results. World Congress on Biomechanics, American Society of Mechanical Engineers Summer Bioengineering Conference. 2014
- Investigation of post-surgical changes to cerebrospinal fluid hydrodynamics in type I Chiari malformation patients. World Congress on Biomechanics, American Society of Mechanical Engineers Summer Bioengineering Conference. 2014
- Machine learning and morphometric analysis of asymptomatic and symptomatic Type I Chiari malformation patients. World Congress on Biomechanics, American Society of Mechanical Engineers Summer Bioengineering Conference. 2014
- Numerical Simulation of Superior Sagittal Sinus Hemodynamics. World Congress on Biomechanics, American Society of Mechanical Engineers Summer Bioengineering Conference. 2014
- Quantification of neural tissue deformation in type I Chiari malformation patients pre- and post-spinal decompression surgery and comparison to controls. World Congress on Biomechanics, American Society of Mechanical Engineers Summer Bioengineering Conference. 2014
- Quantitative Comparison of 4D Phase-Contrast Magnetic Resonance Imaging and Subject-Specific Computational Fluid Dynamics Simulation of Cerebrospinal Fluid Velocities in Cervical Spine. World Congress on Biomechanics, American Society of Mechanical Engineers Summer Bioengineering Conference. 2014
- An in vitro hydryodynamic model of the spinal subarachnoid space with arachnoid trabeculae. Midwest American Society of Biomechanics Regional Meeting. 2014
- Machine learning for the detection of type I Chiari malformation without using tonsillar herniation measurement. Midwest American Society of Biomechanics Regional Meeting. 2014
- Quantification of axial spinal cord displacement in type I Chiari malformation. Midwest American Society of Biomechanics Regional Meeting. 2014
- Measurement of brain and spinal cord tissue motion in type 1 Chiari malformation by phase contrast magnetic resonance imaging. University of Akron, Student Innovation Symposium. 2014
- Syrinx Formation over 1 week in Chiari I Malformation: CSF velocity quantification before and after surgery. AANS/CNS Section on Pediatric Neurological Surgery. 2013
- MRI-based Classifiers in Chiari Malformation. Midstates Conference for Undergraduate Research in Computer Science and Mathematics. 2013
- Cerebrospinal fluid dynamics in the cervical spine: importance of fine automated structures. American Society of Mechanical Engineers - Summer Bioengineering Conference. 2013
- 4D MRI flow quantification of cerebrospinal fluid motion in the cervical spine in healthy subjects and Chiari malformation patients: how do the results compare with 3D computational fluid dynamics?. American Society of Mechanical Engineers - Summer Bioengineering Conference. 2011
- Continuous positive airway pressure impacts cerebral blood flow and cerebrospinal fluid motion: a phase contrast MRI study. American Society of Mechanical Engineers - Summer Bioengineering Conference. 2011
- Prediction of the impact of craniospinal compliance on the relative timing of arterial and cerebrospinal fluid pulsations and perivascular fluid flow into the spinal cord. American Society of Mechanical Engineers - Summer Bioengineering Conference. 2011
- The effect of continuous positive airway pressure on total cerebral blood flow in 23 healthy away volunteers. American Society of Mechanical Engineers - Summer Bioengineering Conference. 2011
- Pathological biomechanics of cerebrospinal fluid pressure in syringomyelia: fluid structure interaction of an in vitro coaxial elastic tube system. American Society of Mechanical Engineers - Summer Bioengineering Conference. 2009
- Towards non-invasive assessment of the elastic properties of the spinal aqueduct. American Society of Mechanical Engineers - Summer Bioengineering Conference. 2009
- Characterization of pressure wave transmission in a fluid filled syrinx. Biomedical Engineering Society Annual Meeting. 2006
- Epithelial cell growth on compliant biomaterial (Nusil CF11). Biomedical Engineering Society Annual Meeting. 2006
- In vitro and in vivo piezoelectric sensor for measurement of pulse wave velocity. Biomedical Engineering Society Annual Meeting. 2006
- Coupled vibration and sound radiation from a fluid-filled and submerged or embedded vascular tube with internal turbulent flow due to a constriction. Meeting of the Acoustical Society of America. 2005
- Helping doctors interpret the sound of blood using a multimode sonic and ultrasonic imaging system. Meeting of the Acoustical Society of America. 2005
- Construction and validation of a complaint model of the cerebrospinal fluid system with fluid filled syrinx. ASME International Mechanical Engineering Congress & Exposition. 2004
- Coupled vibration of a fluid-filled and submerged vascular tube with internal transitional / turbulent flow due to a constriction. Meeting of the Acoustical Society of America. 2004
- Hydrodynamics of cerebrospinal fluid in spinal canal with Chiari malformation and syringomyelia. Bioengineering Session, American Society of Mechanical Engineers National Conference. 2004

presentations

Research

principal investigator on

Biomechanical Characterization and Modeling of Arachnoid Trabeculae in Traumatic Brain Injury awarded by NIH General Medical Sciences 2017
Advanced Ocular and Brain Magnetic Resonance Imaging of Astronauts Following Long Duration Space Flight awarded by NASA 2016 - 2017
Hydrodynamic Simulator for Brain Therapeutic Development awarded by Vandal Ideas Project 2016 - 2017
MRI-based Biomarkers for Amyotrophic Lateral Sclerosis awarded by NIH General Medical Sciences 2016 - 2017
A subject - specific computational simulator of intrathecal drug dispersion in non - human primates awarded by Voyager Therapeutics 2015 - 2016
Identification of MRI parameters and genetic factors for diagnosis of Chiari malformation awarded by Chiari and Syringomyelia Patient Education Foundation 2015 - 2016
MRI morphometric traits of Type 1 Chiari malformation across age and gender awarded by Chiari and Syringomyelia Patient Education Foundation 2015 - 2016
Multicenter in vitro assessment of 4D PC MRI for quantification of CSF motion awarded by American Syringomyelia and Chiari Alliance Project 2013 - 2015

co-principal investigator on

Simulations of CSF, Hemodynamics and Ocular Risk awarded by NASA 2016 - 2019
Highly Accelerated Simultaneous Multi-Slice Phase Contrast MRI awarded by NIH 2016 - 2018
Visualizing Science awarded by Vandal Ideas Project 2016 - 2017
Identification of MRI parameters and genetic factors for diagnosis of Chiari malformation awarded by Chiari and Syringomyelia Patient Education Foundation 2015 - 2016
MRI morphometric traits of Type 1 Chiari malformation across age and gender awarded by Chiari and Syringomyelia Patient Education Foundation 2015 - 2016
A Chiari Malformation MR image database awarded by Chiari and Syringomyelia Patient Education Foundation 2014 - 2016
MRI Based Classification of Chiari Malformation awarded by Chiari and Syringomyelia Patient Education Foundation 2014 - 2015
Metabolic and Inflammatory Alterations in Patients with Chiari Malformation awarded by Chiari and Syringomyelia Patient Education Foundation 2014 - 2015
MRI quantification of brain motion and nerve damage in Chiari I malformation awarded by Chiari and Syringomyelia Patient Education Foundation 2013 - 2015
Transcriptional profiling and µCT assessment of a syringomyelia rat model awarded by Chiari and Syringomyelia Patient Education Foundation 2012 - 2015
An in vitro assessment of 4D PC MRI quantification of cerebrospinal fluid dynamics awarded by Swiss National Science Foundation 2014
Development of a coupled hydrodynamic model of the cardiovascular and cerebrospinal fluid system awarded by Swiss National Science Foundation 2010 - 2013

Background

education and training

Ph.D. in Mechanical Engineering, University of Illinois at Chicago , "Exp. investigation of the hydrodynamic & biomechanical environment present in syringomyelia" 2008
M.S. in Mechanical Engineering, University of Illinois at Chicago 2005
B.S. in Mechanical Engineering, University of Illinois at Chicago 2002
Swiss Federal Institute of Technology (EPFL) , Mentor: N. Stergiopulos 2012

awards and honors

Distinguished Alumni Award, conferred by College of DuPage, 2015
Outstanding Researcher Award, conferred by Conquer Chiari Patient Education Foundation, 2013

Contact

full name

Bryn A Martin

Research Areas

Publications

selected publications

academic article

chapter

conference paper

conference poster