Meiotic Recombination: Crossing over into livestock species. University of Idaho Seed Grant uri icon

Overview

abstract

  • Errors in meiotic recombination are important contributors to aneuploidy, the leading genetic cause of pregnancy loss, birth defects and infertility in mammals. However, limited understanding of the mechanism(s) that govern recombination rates and locations exists. The goal of this study is to establish a technique that uses immunofluorescence to detect chromosomal recombination events in meiotic prophase spermatocytes of livestock species. This goal will both provide important new breed-specific information regarding recombination in livestock as well as contributing to information to enhance our holistic understanding of this process in mammals. My hypotheses are that “recombination rates differ by breed in livestock and males within breeds that exhibit reduced recombination levels are at risk for reduced reproductive success.” The development of this technique will distinguish my lab from all other labs at UI and will allow my research program to be on the forefront of meiotic recombination discovery. Hence the data generated using this novel and sensitive approach will most certainly provide the foundation of future state and federal grant opportunities, for which I will serve as the principal investigator.

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